Table 4 Model input parameters

Cost (2021, Chinese Yuan Renminbi)

 Hospital days

9.9

/

[4]

 Edaravone dexborneol

33

33

49

/

NRDL

 Human urinary kallidinogenase

100

90

100

/

[25]

 Hospitalization costs for mRS (0–2)

12,614

12,428

12,802

gamma(α = 17494.59;β = 0.72)

[31]

 Hospitalization costs for mRS (3–5)

17,223

16,845

17,606

gamma(α = 7860.91;β = 2.19)

 Hospitalization costs for mRS (6)

13,951

12,819

15,155

gamma(α = 548.15;β = 25.45)

 Post-stroke costs for mRS (0–2)

9,264

8,977

9,558

gamma(α = 3909.41;β = 2.37)

 Post-stroke costs for mRS (3–5)

14,238

13,460

15,049

gamma(α = 1235.08;β = 11.53)

Health utility

 mRS 0

0.95

0.90

1.00

beta(α = 56315.05;β = 2963.95)

[27]

 mRS 1

0.89

0.78

1.00

beta(α = 10469.23;β = 1293.95)

 mRS 2

0.67

0.48

0.86

beta(α = 803.62;β = 395.81)

 mRS 3

0.44

0.20

0.68

beta(α = 172.72;β = 219.83)

 mRS 4

0.16

0.00

0.35

beta(α = 126.72;β = 665.28)

 mRS 5

0.10

0.00

0.28

beta(α = 7.68;β = 69.10)

 Disutility of stroke

0.086

0.060

0.112

beta(α = 38.33;β = 407.36)

Hazard ratios for mortality relative to the general population

 mRS 0

1.53

1.23

1.83

lognormal(α = 0.43;β = 0.10)

[20]

 mRS 1

1.52

1.20

1.83

lognormal(α = 0.42;β = 0.11)

 mRS 2

2.17

2.14

2.20

lognormal(α = 0.77;β = 0.01)

 mRS 3

3.18

3.17

3.19

lognormal(α = 1.16;β = 0.002)

 mRS 4

4.55

4.31

4.78

lognormal(α = 1.52;β = 0.03)

 mRS 5

6.55

6.12

6.98

lognormal(α = 1.88;β = 0.03)

China Life Table (natural mortality rate, per year)

 60–64 years

0.75%

/

[21]

 65–69 years

1.17%

 70–74 years

2.03%

 75–79 years

3.56%

 80–84 years

6.29%

 85–89 years

10.28%

 90 years or older

16.17%

Stroke recurrent rate

 Recurrent rate (0–1 year)

5.9%

/

[23]

 Recurrent rate (1–2 year)

3.6%

 Recurrent rate (2–3 year)

2.5%

 Recurrent rate (3–4 year)

2.2%

 Recurrent rate (4–5 year)

2.2%

 Recurrent rate (5–6 year)

2.7%

 Recurrent rate (6–7 year)

2.7%

 Recurrent rate (7–8 year)

2.3%

 Recurrent rate (8–9 year)

2.8%

 Recurrent rate (9 year and above)

1.6%

Others

 Discount rate of cost

0.05

0.00

0.08

/

[15]

 Discount rate of health outcome

0.05

0.00

0.08