Table 3 Estimated compound SUS and out-of-pocket spending with anti-diabetic therapies (updated in September 6th 2023)
Mean monthly costs (Brazilian real – R$) | Mean annual costs (R$ or Int$) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Drug class / Drug | Price 1 | Price 2 | Price 3 | Price 4 | Mean cost | sd | Market share-adjusted drug cost | Market share-adjusted drug class cost | Mean annual add-on drug class cost (R$) | Mean annual add-on drug class cost (Int$) |
Biguanide | R$ 4,98 | |||||||||
Metformin 850 mg | R$ 2.10 | R$ 2.01 | R$ 3.49 | R$ 2.67 | R$ 2.57 | R$ 0.68 | R$ 4.98 | |||
Sulfonylureas | R$ 7.66 | |||||||||
Glybenclamide 5 mg | R$ 0.99 | R$ 1.05 | R$ 0.63 | R$ 0.63 | R$ 0.82 | R$ 0.23 | R$ 0.36 | |||
Glimepiride | R$ 78.39 | R$ 78.39 | R$ 3.14 | |||||||
Gliclazide 30 mg | R$ 10.48 | R$ 13.92 | R$ 10.28 | R$ 11.56 | R$ 2.05 | R$ 4.16 | ||||
Glitazone | R$ 2.68 | 511.92 | 202.34 | |||||||
Pioglitazone 30-45 mg | R$ 47.00 | R$ 42.00 | R$ 39.00 | R$ 42.66 | R$ 4.04 | R$ 2.68 | ||||
GLP1 receptor agonists | R$ 28.50 | 8.505.54 | 3.361.87 | |||||||
Liraglutide | R$ 686.00 | R$ 482.02 | R$ 496.75 | R$ 554.92 | R$ 113.75 | R$ 23.60 | ||||
Semaglutide | R$ 774.00 | R$ 1017.00 | R$ 797.00 | R$ 862.67 | R$ 134.15 | R$ 4.90 | ||||
DPP4 inhibitors | R$ 21.13 | 2.304.84 | 911.00 | |||||||
Vildagliptin 50 mg | R$ 80.89 | R$ 68.98 | R$ 63.90 | R$ 71.26 | R$ 8.72 | R$ 8.55 | ||||
Sitagliptin 50 mg | R$ 116.03 | R$ 142.23 | R$ 129.13 | R$ 18.53 | R$ 10.33 | |||||
Alogliptin 25 | R$ 75.88 | R$ 67.42 | R$ 63.03 | R$ 68.77 | R$ 6.53 | |||||
Linagliptin 5 mg | R$ 195.25 | R$ 254.06 | R$ 224.66 | R$ 41.59 | R$ 2.25 | |||||
SGLT2 inhibitors | R$ 43.18 | |||||||||
Dapagliflozin 10 mg | R$ 99.80 | R$ 95.60 | R$ 147.99 | R$ 114.46 | R$ 29.11 | R$ 17.86 | 1.373,52 | 542.89 | ||
Empagliflozin 25 mg | R$ 182.89 | R$ 251.59 | R$ 282.08 | R$ 182.89 | R$ 224.86 | R$ 50.03 | R$ 25.32 | |||
Insulin | ||||||||||
Regular | R$ 21.00 | R$ 23.12 | R$ 23.76 | R$ 22.63 | R$ 1.45 | R$ 1.13 | R$ 1.13 | |||
NPH | R$ 18.81 | R$ 16.88 | R$ 19.79 | R$ 18.49 | R$ 1.48 | R$ 2.59 | R$ 2.59 | |||
Total monthly cost in reais (Brazilian real – R$) | 111.85 | |||||||||
Total annual cost in reais (Brazilian real – R$) | 1.342.21 | |||||||||
Total annual cost in purchase parity-adjusted Int$ | 530.52 | |||||||||