Fig. 4

Cost-effectiveness planes for 12 cycles (12 years) departing from the age of 60 years-old, T2DM with mean 10 years since diagnosis and recent diagnosis of cardiovascular disease (departing from state C). The model considered an age-dependent progressive increase in transition probabilities as described in Table 1. a. sensitivity analysis considering 5% discount rates for costs and effectiveness for each add-on therapy. b. cost-effectiveness chart comparing incremental cost and effectiveness of pioglitazone, SGLT2i, and GLP-1A on top of standard therapy. c. cost-effectiveness acceptability curve